High-Protein Diets & Weight Loss: What the Evidence Actually Says

Published 8/17/2025

Before/after style illustration focusing on lean mass retention

High-protein diets have become a go-to strategy for weight loss, but what does the science show?

Why Protein Helps

  • Satiety: Protein keeps you fuller for longer.
  • Thermic Effect: Protein costs more calories to digest than carbs or fats.
  • Lean Mass Retention: Higher protein intake helps preserve muscle during weight loss.

What the Evidence Says

  • A 2021 systematic review found that high-protein diets led to slightly greater fat loss and better lean mass retention compared to lower-protein diets.
  • Effects are modest but consistent across randomized controlled trials.

Practical Takeaways

  • Bumping protein to the higher end of the AMDR (25–35% of calories) can help during fat loss.
  • Focus on whole, lean protein sources rather than relying only on shakes.

References:

Explore more articles from Eatyourmacros.

View all posts